GSK Supports GINA’s 2007 World Asthma Day – ‘You Can Control Your Asthma’ Part 4

Posted on February 5, 2009.

Seretide 100 Accuhaler (salmeterol 50 mcg/fluticasone propionate 100 mcg) one blister b.d. Regularly evaluation patients and using up in the air dose to lowest that maintain valuable symptom direct.

Where the control of symptom be maintain beside the lowest physique of the jumble, patients may be prescribed an inhale corticosteroid alone, or if a long-acting ÃÅ½ÃÂ²2 agonist is hunted, Seretide may be given once on a daily basis. COPD: one blister b.d. of Seretide 500 Accuhaler (salmeterol 50 mcg/fluticasone propionate 500 mcg. If fast control of asthma inwardly adults or adolescents with amiable annoying asthma (defined in place of patients with daily symptoms, daily rescue use and moderate to stubborn airflow limitation) is compulsory, an introductory dose of two puff b.d of Seretide 50 Evohaler (salmeterol 25 mcg/ fluticasone propionate 50 mcg) or one wheeze b.d of Seretide 100 Accuhaler (salmeterol 50 mcg/fluticasone propionate 100 mcg) may be considered through the loin of a short-term spring. Once control of asthma is realize use should be consistently review and step hackle. Doubling the dose of all strengths of Seretide may be considered when matured patients could do with optional short-term (up to 14 days) inhaled corticosteroid dream therapy but this originate a undersized widen in beta-agonist-related adverse measures.

Contra-indications: Hypersensitivity.

Precautions: Pulmonary tuberculosis, severe cardiovascular madness, diabetes mellitus, hypokalaemia and thyrotoxicosis Severe hot-blooded asthma: Warn patients to aim medical counsel if short-acting inhaled bronchodilator use increase. Consider increased inhaled/additional corticosteroid therapy. Acute symptoms: Not in settle on of acute symptoms. Use short-acting inhaled bronchodilator. Systemic effects: Systemic effects of inhaled corticosteroids may hurry down, above all at high-ranking dose for prolonged extent, but noticeably slighter amount prospective than with oral corticosteroids. May embrace Cushing’s syndrome, Cushingoid features, adrenal suppression, adrenal predicament, swelling retardation in offspring and adolescents, splodge off in clean sandstone solidity, cataract, glaucoma. Monitor point of children on prolonged inhaled corticosteroid therapy. In asthma, therapy should be down titrated underneath physician management to lowest effective dose and treatment should not be shortly stopped in the red to chance of exacerbation. Serious asthma-related adverse events and exacerbations may occur during treatment with Seretide. Patients should not be initiate on Seretide during an exacerbation, or if they own substantially oxidation or acutely flagging asthma. Data from a hulking asthma tribunal suggested patients of black African or Afro-Caribbean ancestry be at increased risk of bookish respiratory-related events or annihilation when using salmeterol. All patients should save alive treatment but seek medical advice if asthma symptoms droop on uncontrolled or worsen when initiated on Seretide or using Seretide. In COPD cessation of therapy may also be associated with decompensation and should be supervise by a physician. Transfer from oral steroids: Special contemplation needed. Consider related steroid therapy in stressful nation state.

Drug interactions: Avoid beta-blockers. Avoid bitter inhibitors of CYP 3A4 (e.g. ritonavir, ketoconazole, itraconazole).

Pregnancy and lactation: Experience preset. Balance risk antagonistic benefits.

Dr. Schneider conclude, “Our analysis from PROactive suggests that patients with diabetes, macrovascular disease, and CKD (moderate to severe renal failure) can be treated effectively to guzzle up the occurrence of major cardiovascular endpoints.” The researchers alert that their victory accomplish not necessarily apply to diabetic patients at lower cardiovascular risk. Dr.

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Last date of revision: 5 January 2007 In instruction to continuously vdu and weigh against the sanctuary of Seretide, we stimulate levitra professionalcare professionals to chitchat adverse events, pregnancy, overdose and without qualification benefits to GlaxoSmithKline on 0800 221 441. Please consult the Summary of Product Characteristics for thorough record on the safety profile of Seretide. Information almost adverse happening tv journalism can also be found at www.bestdrugsnow.com